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Furthermore, researchers noted that the use of combination therapy, consisting of doxorubicin and Navitoclax (responsible for removing aging cells), led to only a 20% decrease in the running activity of p16-3MR mice, compared to the therapy with doxorubicin alone, where this coefficient reached 50% [60]

The passage of metabolites such as ATP, adenosine diphosphate (ADP), pyruvate, calcium ions (Ca 2+ ), and phosphate (PO 4 ) is regulated by controlling the transport proteins

Salt-sensitive hypertension in mitochondrial superoxide dismutase deficiency is associated with intra-renal oxidative stress and inflammation

It could be speculated that excessive intake of leptin during lactation might not provide greater protection against excess weight gain or could even favour the development of leptin resistance later in life, although these possibilities have not been specifically addressed

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