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Pulmonary hypertension and reduction of the vascular bed due to emphysema can lead to right ventricular hypertrophy and right heart failure, but right ventricular function appears to be maintained in some patients despite the presence of pulmonary hypertension 108

In multiple animal and in-vitro studies, both peptides have demonstrated high tolerability and absence of systemic toxicity

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Ferrostatin-1 was used as an antioxidant positive control

doi: 10.1016/j.coi.2006.05.002 138 CerwenkaALanierLL