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160 In Ang II-infused mice overexpressing CYP2J2 specifically in cardiomyocytes, cardioprotection was linked with the activation of peroxisome proliferator-activated receptor (PPAR)-, reduced oxidative stress, a decrease in nuclear factor (NF)-B p65 nuclear translocation, and inhibition of transforming growth factor (TGF)-1/Smad pathway

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Reddy SM, Kopetz S , Morris J, Parikh N, Qiao W, Overman MJ, Fogelman D, Shureiqi I, Jacobs C, Malik Z, Jimenez CA, Wolff RA, Abbruzzese JL, Gallick G, Eng C

Curr Top Med Chem 20(9):759769 Kamal H, Tan GC, Ibrahim SF, Shaikh MF, Mohamed IN, Mohamed RMP, Hamid AA, Ugusman A, Kumar J (2020) Alcohol use disorder, neurodegeneration, Alzheimers and Parkinsons disease: interplay between oxidative stress, neuroimmune response and excitotoxicity

Consider two research mindsets: A lab interested in a simpler baseline protocol may prefer a single scheduled administration for cleaner comparison