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It is mostly observed that higher disease activity scores are equivalent to low levels of vitamin D, and therefore low levels can be implicated in worsening symptoms and overall poor health outcomes in these patients (169)

Rahman M, Jackson LK, Johnson WE, Li DY, Bild AH, Piccolo SR

Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-12,14-Prostaglandin J2Is Mediated by the Stress Response Elements and Transcription Factor Nrf2

These findings highlight the importance of the CB 1 R in OPC differentiation, and its relationship with the RhoA/ROCK pathway