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Vitamin, mineral, and other nutrient depletion is an effect of taking these drugs that has been documented since the 1960s, leading many researchers and pharmacists to recommend supplementing with vitamins and minerals while using these medications

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22 Notably, both HIF1 and NFB-expressing fibroblasts undergo mitophagy, produce more lactate and stimulate the growth of human breast cancer xenografts, by up to 3-fold

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