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We have shown recently that an invasin coat replaces the use of Matrigel in 2D organoid sheet cultures 48

doi: 10.1016/j.jddst.2023.104876 178

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In order to maximize the clinical utility, various biomimetic approaches have been adopted to enhance or optimize the integrin-mediated cellular interactions and adhesion, including incorporation or surface modification with bioactive molecules or bioadhesive ECM motifs, and macro- or nano-scale patterning of the biomaterials [181]

The secretory activity of microglia plays an essential role in the maintenance of synaptic function, the proliferation and maturation of oligodendrocytes and the recruitment of other immune cells