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Nrf2 tends to promote the transcription of genes by heterodimerizing with Maf proteins or other homologs to a cis-acting DNA transcriptional regulator, specifically the antioxidant response element (ARE) (Zhu et al., 2016)

Several mental disorders come under NPDs, such as anxiety, depression, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and others like schizophrenia, bipolar disorder, mania, Parkinsons disease, Tourettes syndrome, delirium, dementia, vascular cognitive impairment and apathy