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There was no significant association between white matter hyperintensity burden and CSVD features such as lacunes and enlarged perivascular spaces and pial collateral supply

This finding should not be interpreted as a new result but as convergent evidence, corroborating the primary item-level analyses

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a G protein-coupled receptor that mediates vision in dim light by controlling activity of transducin, a G protein an enzyme that catalyzes the conversion of ATP into cytoplasmic 3',5'-cyclic adenosine monophosphate (cAMP) an ion channel that allows transmembrane passage of calcium ions in a manner that is regulated the membrane voltage gradient proteins that bind G protein-coupled receptors to inhibit signaling through G protein activation and ultimately, to permanently terminate signaling by promoting endocytotic internalization and degradation of the receptor