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To inform the development of updated WHO guidelines and expanded treatment criteria, we conducted a systematic review and meta-analysis and provided summary estimates of the efficacy of antiviral therapy in groups stratified by baseline VL ( 18 years and 13 (31%) in those 20,000 IU/mL

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These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm