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The absence of new OLGs in shadow plaques led the authors to conclude that myelin repair in the human brain does not stem from OPCs, instead originating from surviving OLGs that form new myelin sheaths

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Each biopsy was fixed in 10% formalin, routinely processed, embedded in a paraffin block, sectioned by the ordinary microtome into 5 m thick sections and stained with hematoxylin and eosin (H and E) and Masson fontana (MF) for detection of melanin

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Salaiza-Suazo et al, 2024))