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Injectable B12, which is often recommended in severe deficiency cases, may cause more adverse effects, including diarrhea, itching, skin rash, headache, dizziness, nausea, or vomiting

The MPC moiety, acting as an ACh analog, binds specifically to ACh receptors abundantly expressed in brain microvascular endothelial cells and neurons, enabling the S/Ce-PABMS to efficiently cross the BBB and accumulate in target neurons (Fig

No procedure required

This marked it as the first dual GLP-1 and GIP receptor agonist for this purpose

Additionally, the presence of poloxamer 407 on 8314 MAb/BCNU-SLNs induced cytotoxicity in RAW264.7 cells and impeded phagocytosis by these cells