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hypoxia-inducible factor-1 (HIF-1) not only shifts cells to glycolysis but also diverts glycolytic intermediates into the serine/one-carbon pathway, increasing serine synthesis and downstream folate metabolism [24]

Further MR-Egger analysis validated the lack of heterogeneity ( p = 0.564) and pleiotropy ( p = 0.800)

10.1186/s12951-024-02434-3 J Nanobiotechnology

doi: 10.1016/j.ebiom.2019.10.059 7 SuLZhangJGomezHKellumJAPengZ