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GPX4 binds to reduced GSH through its selenocysteine residue and catalyzes the reduction of lipid peroxides, converting the peroxyl bond into a non-toxic hydroxyl radical, thereby maintaining the stability of cell membrane lipids (159)

In vivo studies using animal models have further validated the efficacy of cannabinoids in reducing tumour burden and increasing treatment response (Hinz and Ramer 2022)

Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities

GSH deficiency has been associated with increased ROS and more severe clinical COVID-19 (Guillin et al., 2019