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Primary antibodies recognizing GPX4 (ab125066), SLC7A11 (ab307601), and goat antirabbit IgGHRP (ab150077) were obtained from Abcam (Cambridge, UK)

154 Function in neurodegenerative diseases Alzheimers disease Alzheimers disease (AD) affects ~50 million people worldwide and is characterized by cognitive impairment that is associated with a progressive decline in memory, impaired self-care, disorientation, and personality changes

To meet this daily need for 2 x 10 20 atoms (or 20 mg) of elemental iron, the body has developed regulatory mechanisms whereby erythropoiesis profoundly influences iron absorption

Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab

They modulate redox-sensitive pathways such as those mediated by mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and some tyrosine phosphatases