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Both mean BSC spectrum-based and mean GLCM-based measures exhibited significant spatial differences across presurgical and 1-month/2-month time points, distal stumps enclosed proximity to the injury site being particularly affected

These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling

M.PetersS.PossemiersS.Van DuynhovenJ.VaughanE

A Phase 2 trial combining BPC-157 analogs with fluoxetine halted early in 2024 due to behavioral hyperactivity in rodent models at doses previously considered safe independently

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