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At the same time, the number of senescent cells, associated with damage or stress that secretes proinflammatory factors (SASP or senescence-associated secretory phenotype), increases with age in many key tissues, including the kidneys, lungs, blood vessels, and brain SAM may not get the same level of media attention as NAD+, but that doesnt stop it from being less useful: S-adenosylmethionine, or SAM, has been used for several years in the treatment of hepatic conditions and osteoarthritis and more recently in the treatment of clinical depression

A clinically complete approach therefore requires going beyond hemoglobin correction and addressing the broader biological imbalance, including bone marrow function, organ protection, metabolic stability, and overall physiological resilience

This peptide is naturally expressed in various tissues and also circulates in the bloodstream, acting in both a local (cell-specific) and hormone-like manner

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