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synthetically generated CpG containing hexamers &/or oligos containing CpG containing hexamers poly A, C, G, T, etc

Dexamethasone-loaded biopolymer-lipid hybrid microcarriers have been developed for inner ear delivery and sustained release (Dindelegan et al., 2022)

So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation