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Together these findings, therefore, suggest that alsin protects cells from oxidative stress and could be a redox sensing protein, similar to Rab5, Rac1, and SOD1

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Of note, larvae inside eggs that we obtained from both the 23% and 25% sucrose layers appeared fully embryonated and were therefore pooled and used for all subsequent in vitro assays

Second, knockout of alsin in mice is not sufficient to trigger motor neuron degeneration, but neurons cultured from these animals are more susceptible to oxidative stress (Cai et al., 2006

Independent of loss of kidney function, a rise in BUN may also occur as a result of hypercatabolism from the excess breakdown of amino acids