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the main quantity, however, only afterbonding to the intrinsic factor, a mucoprotein, which bonds the cobalamins instoichiometricproportions

*Correspondence: Zhigang Ren, [email protected] Yu, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This investigator's evaluation of a drug that is still undergoing the pre-approval process makes a Phase 4 trial unlikely