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Interestingly, even in patients with an excellent virological response to long-term antiretroviral therapy, such as HIV-infected children, the accumulation of mtDNA mutations persists (143), highlighting the long-term impact of the virus or treatment on mitochondrial genetics

All experimental procedures using these mice were performed in accordance with a research protocol approved by the Institutional Laboratory Animal Care and Use Committee of SYUCC (L025504202205013)

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