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Hyperthermia is a promising treatment option for several types of cancer, including non-small cell lung cancer (Wang, Lin 2013), bladder cancer (Colombo 2013

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These drugs include monoclonal antibodies targeting Wnts and FZD receptors, molecules inhibiting their secretion and interaction, and small molecule inhibitors that stabilize the -catenin destruction complex and block the binding of -catenin to specific transcription co-activators ( Table 1 )

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This triple signaling suppresses appetite, slows gastric emptying, enhances insulin sensitivity, and raises basal energy expenditure through glucagon-mediated thermogenesis