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vascular endothelial growth factor (VEGF) and angiopoietin-1, leading to the induction of genes involved in angiogenesis and thus represent therapeutic targets for the inhibition of tumor angiogenesis [122]

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Fluoroquinolone antibiotics can form zwitterion coordinated with Cu 2+ through the pyridone carbonyl oxygen and carboxylate oxygen, or anionic bidentate ligand coordinated through the pyridone carbonyl oxygen and carboxylate oxygen (Nedeljkovi et al

By a variety of mechanisms, NO can react with different molecules, under ambient oxygen, and the derived products can damage the cellular macromolecules, such as lipids, DNA bases, proteins as well as thiols