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STK32B (serine/threonine kinase 32B), PPARGC1A (PPARG Coactivator 1 Alpha), CTNNA3 (Catenin Alpha 3) The third GWAS (two-stage) conducted so far, exploring the genetic susceptibility of ET included 2807 patients with ET and 6441 controls of European ancestry

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A 2025 independent study replicated some of the in vitro telomerase findings, which is a promising development, but the gap between Russian-led research and Western validation remains real