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Alimta is contraindicated in pregnant women due to potential harm to the fetus, and women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose

Ceramides, which are elevated in both GWS and ME/CFS, are implicated in the activation of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor (TNF-) within immune cells such as macrophages, as well as in serum (Germain et al., 2020

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Combined with the understanding of tumor somatic cell evolution, it can provide a basis for the development of a treatment framework to guide patient immune stratification and immunotherapy decisions

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