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For example, compared to a simpler design ( 1a R -IN-8), kinome-wide selectivity (see 1a R -IN-8 vs 6 S,S -IN-8) or JNK isoform selectivity (see 1a R -IN-8 vs 1b R -IN-8), and even inhibitor efficacy on c-Jun substrate phosphorylation in cells (see Table 1), could be improved by changing the warhead scaffold at this accessible position

Bae H, Yang C, Lee JY, Park S, Bazer FW, Song G, et al

Static stabilizers include the joint capsule, the glenoid labrum, and the glenohumeral ligaments

employed the use of restriction endonucleases and mitochondrial transcription activator-like effector nucleases (mito-TALENs) to selectively eliminate mitochondrial genomes from a heteroplasmic mouse (Reddy et al., 2015)

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