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Additionally, partially substituting zinc with more biocompatible metals (such as magnesium or calcium) within the MOF structure can stabilize the framework and diminish toxic ion release ( in vitro and in vivo models, are crucial for achieving a balance between efficacy and safety

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Specifically, the Lactobacillus lactis strain was genetically engineered to produce human proinsulin (PINS) and human IL-10 (hIL10), named GM L