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doi: 10.1016/j.carbpol.2015.07.065

This transition ensures the molecular fuse remains stable in systemic circulation while facilitating rapid release only upon interaction with the targeted pathogen environment ( 2.3 Payload design: beyond cytotoxicity The payload objective shifts from inducing apoptosis in host cells (Onc-ADCs) to selective pathogen lethality (ID-ADCs) ( Riaz et al., 2025 )