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To account for the continuing degeneration and atrophy in later stages, in the face of waning adaptive inflammation as the disease progresses, it has been proposed that the inflammation becomes trapped behind the bloodbrain barrier, continuing to damage the CNS, but now being inaccessible to peripherally-administered immunosuppressants

10.1016/j.jacc.2020.11.044 39 GettingerS.LynchT

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Incubate for 15-30 minutes

human evidence is limited and the combination is unstudied, so individual results vary