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The overexpression of metrnl induces the expression of SIRT3 by promoting the expression of transcriptional activator PGC-1, increasing the expression level of UCP1 and the activation of AMPK in PA-treated RTECs to accelerate mitochondrial autophagy, maintain mitochondrial homeostasis, and alleviate lipid accumulation (a thermogenic factor) (Zhou et al., 2023)

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Ma (49) pointed that dietary intake of flavonols (quercetin and isorhamnetin) is associated with the development of age-related cataracts, and increasing dietary intake of quercetin and isorhamnetin may result in a lower risk of age-related cataracts

Critics argue that the FDA's caution could restrict access to a potentially beneficial compound, advocating for a more balanced approach that considers BPC-157's therapeutic potential

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