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Accumulating evidence suggests that non-apoptotic forms of programmed cell death (e.g., parthanatos, necroptosis) and dying-back degeneration of axonal terminals may be more important in the early stages of the disease [40]

In some embodiments, a substantially pure composition comprises a composition that contains greater than 80% macromolecular species (e.g., active agents, gene silencing agents, siRNA molecules, other agents (e.g., antioxidants))

Macchiaiolo M, Buonuomo PS, Valente P, Rana I, Lepri FR, Gonfiantini MV

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