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This kind of compounds shows a high specificity for IRAP against APN (Compound 8 IC 50 = 5.8 M) and according to docking studies, the inhibitor acts in a binding pocket close to the GAMEN loop without interacting with the zing atom, leading to uncompetitive inhibition, confirmed later on by kinetic studies

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Case reports have described thrombocytopenia and altered aggregation, but the condition is rare and the mechanism not fully characterized

Reduced mitochondrial number and their increased deformation may damage the normal oxidative decomposition of fat, thereby increasing hepatic fat content