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c Stress-induced changes in H 2 O 2 and NO levels as well as antioxidant enzyme activities (general tendency)

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Additionally, NRF2 also regulates the expression of the solute carrier family 7 member 11 (SLC7A11), which encodes the cystine/glutamate transporter XCT [23]

2.3 PBPK model validation 2.3.1 PBPK model validation: PK simulations for S-CIT To validate the developed PBPK model of S-CIT, eleven clinical datasets (seven single-dose studies and four multiple-dose studies) were used