methamphetamine also has a ~ 2 fold higher affinity (lower IC 50 ) for inhibiting SERT compared to amphetamine (Rickli et al, 2015) Indications: Attention-deficit disorders in children over 6 years of age Short term treatment for obesity (Exogenous Obesity) - however its use is controversial and often not recommended
EMBO J 8: 24172424
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Common Symptoms of a Sulfa Allergy Can Include: Skin rashes or hives (most common) Fever Swelling of the face, mouth, or tongue Stomach cramps In severe cases, anaphylaxis Drugs commonly linked to Sulfa Allergy: Antibiotics Sulfamethoxazole (Co-trimoxazole, Bactrim, Septra) Sulfadiazine Sulfisoxazole Anti-inflammatory / Autoimmune Sulfasalazine Dapsone Diuretics Thiazides (Hydrochlorothiazide, Chlorthalidone, Indapamide) Loop diuretics (Furosemide, Bumetanide, Torsemide) Carbonic anhydrase inhibitors (Acetazolamide, Dorzolamide, Brinzolamide) Antidiabetic agents Sulfonylureas (Glibenclamide, Glipizide, Glimepiride, Gliclazide) Others Celecoxib (COX-2 inhibitor NSAID) Probenecid Key takeaway: Not every patient with a sulfa allergy will react to all sulfonamide drugs but vigilance saves lives
doi: 10.1038/sj.emboj.7601116 6 Al-RomaiyanA.BarakatA.JoseL.MasochaW
