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10.3389/fphar.2020.603235 82 SantucciR.SinibaldiF.CozzaP.PolticelliF.FiorucciL

Importantly, amino acid metabolism links to epigenetic regulation through production of metabolites like S-adenosylmethionine (SAM) and acetyl-CoA, influencing gene expression patterns that drive tumor progression [35,36,37,38,39]

However, there is compelling evidence that caspase-3 and caspase-8 are downstream effectors of the Fas cell death signaling pathway, indicating their importance for extrinsic Fas-mediated eryptosis (see the Extrinsic Fas-mediated eryptosis section) [130, 136]

In the present study, we show that depletion of cellular GSH by BSO sensitizes antihormone-resistant MCF-7:2A cells to estradiol-induced apoptosis that is mediated, in part, by the mitochondrial pathway and also activation of the c-Jun N-terminal kinase (JNK) signaling pathway

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