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Bromodomain -4 is a transcriptional regulator which promotes disease progression in DCM which can bind to the promoters of multiple metabolic genes and importantly regulate the p65 expression of the inflammatory NF-kB pathway in the beta cells (130)

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Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody

Tumor-derived factors, such as GM-CSF, TNF-, IL-6, HMGB1, and CCL20, upregulate PD-L1 expression on neutrophils, suppressing T cell activity and facilitating immune evasion by the tumor