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doi: 10.1021/acs.nanolett.4c03788 149 ZhangXDouYLiuSChenPWenYLiJet al

RSL RAS-selective lethal VDAC2/3 voltage dependent anion channels 2 and 3 ShRNA and cDNA overexpression studies demonstrated that VDAC2 and VDAC3 are necessary, but not sufficient, for erastin-induced death (Yagoda et al., 2007), indicating that additional unknown targets are required for this process

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While all these completed trials studied combinations of chemo- and targeted therapies only, 3 ongoing trials are now investigating the addition of IVC to targeted agents only (eg