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In the external cohort high-risk tumors, there was increased recruitment/infiltration of granulocytic populations (including neutrophils/eosinophils) and upregulation of proliferative/cell-cycle and metabolic programs (E2F targets, glycolytic metabolism, G2/M checkpoint) ( Further studies are warranted to better validate and classify gene expression pathways that are dysregulated in TDLN with metastasis, which may provide novel targets of therapy

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10.1186/s13045-017-0505-0 J Hematol Oncol

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