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Although this may reflect differences in absorption, distribution, and elimination, differences in drug metabolism also plays a role

This metabolic shift happens through PI3K-Akt-mTOR pathway activation, leading to increased glucose transporter (GLUT1) expression and glucose uptake [20]

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Overdose symptoms are severe, prolonged, and disablingintense vomiting, incapacitating abdominal pain, and symptoms that worsen rather than improve over 24-48 hours signal overdose and require medical evaluation