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Suppression of SLC7A11 is also linked to T cell memory-associated enhanced immune responses ( Resistance to Cancer Therapy SLC7A11 overexpression is associated with resistance to immunotherapy, as well as chemo- and radio-resistance, including to drugs such as gemcitabine and cisplatin (84)

1, thiol-mediated metabolism of DSF and RS-DDTC releases DDTC that can chelate divalent (e.g., Mg 2+ , Cu 2+ , Zn 2+ ) and trivalent (e.g., Fe 3+ ) metals in the cell