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doi: 10.1016/j.celrep.2023.112852 151 NakamuraSObaMSuzukiMTakahashiAYamamuroTFujiwaraMet al

Virant-Klun, I., Imamovic-Kumalic, S

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Dysregulation of autophagy, endolysosomal trafficking, lysosomal function, and mitochondrial integrity not only promotes neuronal dysfunction and death but also contributes to protein aggregation, neuroinflammation, and disease propagation across neural networks

We have also recently reported that GRK4 increases the phosphorylation of angiotensin II type 2 receptor (AT 2 R) which impairs renal AT 2 R-mediated diuresis and natriuresis, which participate in the GRK4-mediated regulation of blood pressure [93].In addition to dopamine and Ang II receptors, GRK4 also regulates other receptors such as the endothelin type B receptor (ETBR) and AdipoR1