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gingivalis LPS) significantly downregulated both the transcription and protein expression of SLC7A11 via the TLR4/NF-B pathway, inhibiting cystine uptake, leading to insufficient GSH synthesis and loss of GPX4 activity (40), thereby directly impairing cellular antioxidant capacity

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While the role of itaconate in limiting inflammation has been studied in peripheral macrophages, its immunometabolic function remains unexplored in HIV and cocaine-exposed microglia