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Drug development has a well-documented failure rate: roughly 90% of compounds that show promise in animal models fail in human trials

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Marked elevations in liver function test results (e.g., AST [SGOT] and ALT [SGPT]), occurred on 2 occasions following administration of high doses (total doses: 106 and 250 g over 3-4 days) of acetylcysteine rectally and via nasogastric tube in a 3-year-old boy with cystic fibrosis

An intensive search to discover biomarkers to optimize response to anti-TNF- treatment is currently ongoing

For brain homogenates, 0.2 ml of the preparation was diluted to 1 ml by the respiration buffer