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Additionally, the multifunctional hydrogel PAN/Ag-PLG has been reported to combine strong tissue adhesive with easy detachment properties (Zhai et al., 2025)

In addition, a negative correlation exists between zinc finger transcription factors (Snail, Slug, Twist and ZEB1) and E-cadherin expression

Taken together, these findings position AKT1 not only as a molecular hallmark of advanced lipedema but also as a promising therapeutic target that warrants further validation in preclinical models and pharmacological intervention studies