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This anion then quickly breaks a disulfide bond and leads to Cys 63 nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His 467 ) thus creating a mixed disulfide bond (GS-Cys 58 ) and a GS - anion

All of the compounds above have been proven to maintain GSH contents and GSH-dependent antioxidant enzyme activities in the myocardium, protecting it from oxidative stress [41, 158,159,160,161,162,163,164]

2020;39:e105696

Several studies highlighted the concept that inflammatory conditions affecting the gastrointestinal tract may at least in part contribute to occurrence of genito-urinary disorders, thus being a putative target of intervention (2-4)