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The development of tumours is largely dependent on complex biochemical alterations in the tumour cells themselves and the cellular stroma

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Although angiogenesis is extremely critical in the process of tendon healing, However, studies have shown that chronic tendon injuries are often accompanied by increased neovascularization, when VEGF-induced neovascularization hinders tendon healing ( Basic Fibroblast Growth Factor Promotes Cell Proliferation Tenocytes are the basic functional unit of the tendon which are slow to proliferate due to their being a highly differentiated cell

Alternative mechanisms currently under investigation appear to include potentially peptide-related modulation of energy expenditure and fatty acid oxidation pathways

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