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A global observational clinical study of HD has assessed the effects of metformin on cognition, with linear analysis finding that metformin was related to the better cognitive ability of patients with HD ( Animal experiments have shown that metformin can prolong the survival time of HD transgenic male mice ( via the MID1/PP2A complex and reduced S6 phosphorylation, which completely restored the mices early network activity pattern and behavioral abnormalities

More so, asymptomatic parasitemia in malaria infection is associated with a decreased response to the newer acellular pertussis and meningococcal vaccine (85)