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MAP kinases in inflammatory bowel disease

Largely elevated levels of circulating IGF-I but as a result of absence of proteolysis of IGFBP-5 and IGFBP-3, necessary for disruption of ternary complex formation, IGF-I bioactivity in serum is low and presumably tissue bioactivity of IGF-I (and IGF-II) is low

reports that " mice [exposed] every 48 and 72h reached higher body weight and length than placebo

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