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The rash can be: Itchy and uncomfortable Red, cracked, or sore Dry, scaly, or even blistering Persistent , lasting weeks if you keep encountering the allergen These allergens can be hiding in everyday products like: Makeup & skincare (foundation, shampoo, aftershave) Jewelry (nickel in earrings, watches, belt buckles) Medications (topical creams, antibiotics, adhesives) Work-related materials (cleaning supplies, latex gloves, ink, construction materials) Since many of these substances are found in multiple products , identifying the exact trigger is trickywhich is why patch testing is so important

In this review, no distinction will be made among them as there is currently no clear distinction between SFC (West, 2018)

This action appears to result from a combination of mechanisms including: blocking Na+ channels (possibly the most important mechanism) enhancing GABA-mediated inhibition in the CNS (by increasing GABA levels by a variety of mechanisms) increase in K+ currents block of T-type Ca2+ channels blockade of excitatory NMDA receptor-mediated excitation NOTE: sodium valproate is the salt form of valproic acid

Faizan et al

6LarsonAM, PolsonJ, FontanaRJ,