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In late-stage MASLD or end-stage heart failure, where mitochondria are severely compromised and NAD + depleted, SIRT1 activation may further aggravate oxidative injury by promoting mitochondrial fission and excessive autophagy, depleting cellular energy

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In addition, BACH1 is also polyubiquitinated by Fbox and leucinerich repeat protein 17 (FBXL17) [ 33 , 34 ] and hemeoxidized IRP2 ubiquitin ligase 1 (HOIL1)

Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: a controlled clinical trial

Supercomplexes in the respiratory chains of yeast and mammalian mitochondria