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Suppression of SPTBN2 or enhancement of HAR1A-mediated MYC degradation increases cisplatin sensitivity by inhibiting adaptive autophagy or directly triggering ferroptosis (119,120)

Enzymatic antioxidants, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, neutralize ROS, while non-enzymatic antioxidants like vitamin C, vitamin E, and glutathione protect against cellular damage

To determine the tolerable upper intake level (UL), the FNB selected adverse reproductive effects in rats as the most sensitive index of toxicity and applied a large uncertainty factor because animal data were used (2)

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORt+ T cells

Although several steps forward have been made in order to translate these results into clinical practice, currently there is a gap between preclinical research and clinical trials that need to be filled